07 خرداد 1403
زهرا گرگين كرجي

زهرا گرگین کرجی

مرتبه علمی: استادیار
نشانی:
تحصیلات: دکترای تخصصی / مهندسی پزشکی
تلفن:
دانشکده: دانشکده مهندسی

مشخصات پژوهش

عنوان
The Effect of Pore Morphology and Agarose Coating on Mechanical Properties of Tricalcium Phosphate Scaffolds
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
agarose, biomineralization, bone scaffold, mechanical properties, pore morphology, tricalcium phosphate (TCP)
پژوهشگران زهرا گرگین کرجی (نفر اول)، رضا باقری (نفر دوم)، سوده امیرخانی (نفر سوم)

چکیده

Three-dimensional biocompatible porous structures can be fabricated using different methods. However, biological and mechanical behaviors of scaffolds are the center of focus in bone tissue engineering. In this study, tricalcium phosphate scaffolds with similar porosity contents, but different pore morphologies were fabricated using two different techniques, namely replica method and pore-forming agent method. The samples fabricated using the pore-forming agent showed more than two times higher compressive and bending strength, and more than three times higher compressive modulus. Furthermore, a thin layer of agarose coating, improved the compressive and bending strength of both types of the ceramic scaffolds. Subsequently, the samples’ capability to guide biomineralization was evaluated by immersion into a simulated body fluid which developed Ca-P nano-platelets formation and enhanced the compressive strength. Finally, the MTT assay was used to evaluate L929 cells viability and proliferation on all the samples and it confirmed that cell behavior was not affected by pore morphology or agarose coating. In summary, samples produced by the use of the pore-forming agent showed higher potential to be applied as bone scaffolds in tissue engineering applications.