July 25, 2024
Mohsen Samimi

Mohsen Samimi

Academic rank: Associate professor
Address: Imam Khomeini Highway, Kermanshah, Iran
Education: Ph.D in Chemical Engineering - Biotechnology
Phone: 08338305001
Faculty: Faculty of Engineering

Research

Title
Facile Aqueous Synthesis of Pt-Doped CdTe QDs as Fluorescent Probes for Warfarin Detection in Human Plasma and Urine Samples
Type Article
Keywords
Fluorescence red shift, Pt, CdTe, Quantum dots, Quenching, Warfarin detection
Researchers Mohsen Samimi، hosna ehzari، meysam safari، Azeezah Yaseen Yousif، Jafar Nouri

Abstract

The existence of warfarin is beneficial for health, but its increase in the human body causes toxicity and increases the risk of bleeding. This research focuses on introducing a facile and safe fluorescence sensor for warfarin detection in biological samples. The synthesis of the fluorescence sensor probe was easily performed with doping metal ions of the Pt to CdTe quantum dots. The morphological and optical properties of the synthesized Pt:CdTe quantum dots were characterized by FT-IR, TEM, and EDX. The interaction patterns of warfarin with CdTe QDs were investigated by the quantum chemical method and compared with experimental results. The proposed quantum dots exhibited a blue luminescence with a 28.8% quantum yield. Pt:CdTe QDs were used as the fluorescence probe to assay warfarin. This procedure is based on the "off" fluorescence of quantum dots in the presence of different concentrations of warfarin. Under optimal conditions, the fluorescence sensor probe could detect the concentration of warfarin with a wide linear range of 0.1–100 μM and a detection limit (S/N = 3) of 0.05 µM. Results of sample analysis by fluorescent nanoprobe displayed that this probe could be the potential alternative tool for warfarin detection in biological samples.