This study introduced a new approach to predicting slope factors of safety using a feedforward backpropagation artificial neural network (ANN). Based on a database of 540 cases, this paper investigated the effect of significant parameters such as slope angle, soil friction angle, soil cohesion, slope height, and soil unit weight. The two-hidden-layer ANN architecture consists of ten neurons in each hidden layer utilizing the rectified linear unit activation function for nonlinearity and a linear activation function for the output layer. This architecture could capture complex interactions among input parameters with excellent predictive capability, as seen from R values of 0.95806, 0.9556, 0.94566, and 0.95566 for training, validation, testing, and overall datasets. The model is trained by implementing the backpropagation algorithm with the Adam optimizer and assessed using mean squared error as the loss function. Notably, the findings indicated that ANN cut computational time by about 90% relative to traditional numerical techniques. Enhanced performance of the ANN model not only eases slope stability analysis but also yields a powerful tool for efficient slope stability prediction under different conditions.