This study investigated the removal of an organic drug called ibuprofen from the wastewater containing this drug. Iron oxide supported on modified Iranian clinoptilolite was used as the photocatalyst in the presence of the light of a solar lamp. XRD, SEM, EDAX, and FT-IR analyses were performed to detect the prepared photocatalyst. The results of photocatalytic identification analyses proved the suitable loading of iron oxide supported on modified Iranian clinoptilolite. This study investigated the effect of initial concentration of ibuprofen (5–25 mg/L), photocatalyst concentration (100–300 mg/L), and process time (10–240 min) on the removal from ibuprofen from wastewater containing this drug. The experiments were performed in a setup in the presence of a solar lamp with a flux of 300 W/m2. The results indicated that with the initial ibuprofen concentration of 25 mg/L, photocatalyst concentration of 300 mg/L, and time of 210 min, the highest percentage of ibuprofen removal and ibuprofen adsorbed on the catalyst were 99.80% and 83.17 mg/g, respectively. Kinetic modeling was then performed using the Langmuir–Hinshelwood model, and a quasi-first-order kinetic model showed a good agreement with the results obtained. Finally, the recovery of the photocatalyst was investigated, and the results showed that under optimal conditions about 91% of ibuprofen was removed after five re-uses of the photocatalyst.