Ultrasound as an efficient emerging technology for CO2 desorption enhancement has attracted great attention in recent years. In the present study, a mini-plug reactor was equipped with a 28 kHz ultrasound transducer and employed for CO2 stripping from different amine-based solutions. First, 30 wt% aqueous solutions of MEA, DEA, DIPA and MDEA were investigated under the effect of desorption temperature and flow rate of the solution. 26.4% energy saving and around 70% enhancement in desorption was reached for MEA at 55℃ using ultrasound irradiation. Some novel tri-solvent blends were also studied in the optimum temperature. Among four blended amine solutions, new aqueous solution of MEA+DIPA+AMP showed the maximum desorption rate of 84.2% and minimum regeneration energy of 2.7 MJ/kgCO2 using the designed ultrasound-equipped plug reactor. It was concluded that CO2 desorption from the MEA+DIPA+AMP blend could reduce required energy consumption by around 35% compared to 30 wt% MEA using conventional method. The present study provided an efficient intensified desorber as well as a kind of tri-solvent blend as a brilliant system for CO2 capture process at lower temperature than conventional.