In this paper, the feasibility of using an X-ray tube instead of radioisotope sources for measuring volume fractions of gas, oil, and water in two typical flow regimes of three-phase flows, namely, annular and stratified, is evaluated. This study’s proposed detection system is composed of an X-ray tube, a 1 inch × 1 inch NaI detector, and one Pyrex-glass pipe to model different volume fractions for two flow regimes, annular and stratified. Group method of data handling (GMDH), a powerful regression tool, was also implemented to analyze the obtained data. The obtained results in this work indicate that a simple system based on an X-ray tube and just one NaI detector could be a potential alternative to radioisotope-based systems for separate measurements of gas, oil, and water volume fractions in annular and stratified flow regimes of a three-phase flow.