Covid-19 (2019-nCoV) disease has been spreading in China since late 2019 and has spread to various countries around the world. With the spread of the disease around the world, much attention has been paid to epidemiological knowledge. This knowledge plays a key role in understanding the pattern of disease transmission and how to prevent a larger population from contracting it. In the meantime, one should not overlook the significant role that mathematical descriptions play in epidemiology. In this paper, using some known definitions of fractional derivatives, which is a relatively new definition in differential calculus, and then by employing them in a mathematical framework, the effects of these tools in a better description of the epidemic of a SARS-CoV-2 infection is investigated. To solve these problems, efficient numerical methods have been used which can provide a very good approximation of the solution of the problem. In addition, numerical simulations related to each method will be provided in solving these models. The results obtained in each case indicate that the used approximate methods have been able to provide a good description of the problem situation.
