Honeycomb structures are widely used in various aspects of the industry, such as aerospace, marine, automotive, and medicine. Improving the mechanical properties of these structures has received significant attention in recent years. The main aim of the current research is to promote the performance of honeycomb structures by changing the honeycomb cell topology. In this study, a Fibonacci-based pattern was employed to enhance the mechanical performance of conventional honeycomb structures under in-plane compression. The conventinal and Fibonacci-pattern honeycomb samples were manufactured through the fused filament fabrication (FFF) method. Polylactic acid (PLA) filament was used to fabricate the specimens. The 3D-printed samples were tested under in-plane compression loading conditions. It was observed that in the presence of Fibonacci-based pattern, the weight of honeycomb structure is not enhanced significantly. The experimental results manifested that by changing the topology of conventional honeycomb structures, their strength and modulus were increased remarkably