The numerical analysis of water/silver nanofluid (NF) flow in a perforated pin-fin heatsink (PFHS) is performed considering the nanoparticle concentration (φ) of 1% and seven different perforation inclination angles (γ). The configuration with the best hydrothermal performance and the lowest entropy generation rate at different values of Reynolds number (Re) is determined using the two-phase mixture technique. According to the results, the γs of 45º and -45º exhibit the highest heat transfer coefficient (h) and the lowest thermal resistance factor and mean CPU temperature at four studied Res of 500, 1000, 1500, and 2000. Consequently, the highest hydrothermal performance evaluation criterion (PEC) was obtained for the heatsink with γ of 45º followed by γ of -45º at Re of 500; the increase in Re reduced the PEC due to the pressure drop. PEC of the heatsink with γ of 45º was almost 11.06–16.63% higher than that with γ of 0º. In addition, γ of -15º and 45º provided the lowest frictional and thermal entropy generation rates (S˙fr and S˙th) at Re of 1500 and then 2000. S˙fr and S˙th for γ of 45º were 1401% and 97% lower than those for γ of 0º at Re=1500.
