In this study, 1.7 MHz ultrasonic and thermoelectric generators (TEGs) are used to cool down a photovoltaic (PV) module and improve its performance. The PV module is placed on a rectangular enclosure equipped with five ultrasonic piezoelectrics, which produce cold vapor of water inside the enclosure. The hot side of TEGs is attached to the rear surface of the PV module and their left side is cooled using water cold steam generated by ultrasonic piezoelectrics. The outcomes revealed that when the cooling system is not used, Ts,ave increases to about 62.81 ◦C in the steady-state condition, while by using just the TEGs and just ultrasonic (H = 1.5 cm), the Ts, ave is reached 55.4 ◦C and 52.3 ◦C, respectively. The hybrid cooling system of TEGs and ultrasonic reduced the Ts, ave to 48.1 ◦C and increased its output power by 25.7%. By using the proposed cooling system, considering the impact of H on the temperature uniformity of the PV module represents that H = 0.75 cm is an efficient value to achieve high power output. In addition, the electrical efficiency of the PV module at the more efficient condition boosts from 8.61% to 12.46% compared to the non-cooling system.