This study introduces a novel, climate-responsive optimization framework for amine gas sweetening, uniquely developed to address the competing seasonal challenges of winter-phase corrosion and summer-phase dehydration inefficiency-a critical gap in conventional process design. Through high-fidelity simulation validated with real annual operating data from the Ilam Gas Treating Co. (IGTC), we quantify the direct impact of extreme ambient temperature variations (−4°C to 46°C): a 38.4% rise in methyl mercaptan loading and a 35% increase in reboiler acid gas concentration during winter, alongside a 60% elevation in sweet gas water content during summer, which collectively increase corrosion-related leaks by 76.7% in cold months and constrain dehydration capacity in hot periods. The core scientific contribution is the identification of an optimal operating envelope-60.38°C for the absorber and 94.64°C for the regenerator-derived via least absolute deviation (LAD) analysis, which simultaneously minimizes both failure modes. We demonstrate the implementation of this envelope through three scalable engineering interventions: a parallel plate heat exchanger system, a 40% reduction in amine circulation rate, and a redesigned air-cooled exchanger, which together reduce energy consumption by up to 45.3%, increase heat transfer capacity by 44.9%, and enhance sweetening throughput by 2.5%. This work provides the scientific community with a transferable, physics-informed methodology to dynamically synchronize gas processing operations with local climatic conditions, offering a clear pathway toward energy-efficient, corrosion-resistant, and capacity-optimized natural gas processing.