04 خرداد 1403
پيوند واله شيدا

پیوند واله شیدا

مرتبه علمی: دانشیار
نشانی: کرمانشاه، دانشگاه صنعتی کرمانشاه-دانشکده مهندسی-گروه مهندسی شیمی
تحصیلات: دکترای تخصصی / مهندسی شیمی
تلفن: 083-38305004 (1166)
دانشکده: دانشکده مهندسی

مشخصات پژوهش

عنوان
Nucleation Rate Prediction of Curcumin Particles in Microfluidic‐Assisted Nanoprecipitation
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Computational fluid dynamics Liquid antisolvent precipitation Nanoparticles Nuclation rate Population balance model
پژوهشگران پیوند واله شیدا (نفر اول)، الهام میر (نفر دوم)

چکیده

A hybrid computational model was developed to interpret the formation of curcumin particles via liquid antisolvent precipitation (LASP) in three microchannel reactors (MCRs) with different confluence angles. The computational fluid dynamics (CFD) model was numerically combined with a discretized population balance approach. The nucleation kinetics were computed using an expression obtained from the nucleation rate and supersaturation equation from previous experimental data. A quantitative comparison of the particle size distributions (PSDs) demonstrated that the particles with the smallest diameters are observed right after the intersection of the three streams. Besides, the large confluence angle of 135° in the MCR presented higher population density as a result of the smaller size of the precipitated curcumin particles. These findings illustrate the efficient applicability of the hybrid model.