30 خرداد 1403
حامد رشيدي

حامد رشیدی

مرتبه علمی: دانشیار
نشانی: دانشگاه صنعتی کرمانشاه، دانشکده مهندسی، گروه مهندسی شیمی
تحصیلات: دکترای تخصصی / مهندسی شیمی
تلفن: 1169
دانشکده: دانشکده مهندسی

مشخصات پژوهش

عنوان
Statistical optimization of curcumin nanosuspension through liquid anti-solvent precipitation (LASP) process in a microfluidic platform: Box-Behnken design approach
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Anti-solvent, Box-Behnken, Curcumin, Microfluidics, Particle Size, Precipitation
پژوهشگران مسعود رحیمی (نفر اول)، پیوند واله شیدا (نفر دوم)، حامد رشیدی (نفر سوم)

چکیده

The paper deals with the development and optimization of curcumin nanosuspension by solvent/anti-solvent precipitation method in a microfluidic platform. A three-level Box-Behnken design was applied as an optimizing technique to investigate the effect of three independent operating variables, namely, volume ratios of anti-solvent to solvent, flow rate of drug solution, and curcumin concentration on the preferred response. In presence of PVP as the stabilizer, a nano-curcumin suspension was obtained in the range of 62-335 nm. Analysis of variance showed that the variables with the highest effect were the linear effects of the anti-solvent to solvent ratio, and its corresponding squared term. Applying response surface methodology, curcumin nanosuspension with average size of 63.12 nm can be obtained under optimum condition As: S=15, solvent flow rate of 1.0 mL/min and curcumin ethanolic concentration of 5.0 mg/mL. The prepared nanoparticles were further characterized by infrared spectroscopy, scanning electron microscopy, and X-ray diffraction tests.