This paper aims to investigate the hydrothermal and entropy generation characteristics of a non-Newtonian
nanofluid containing CuO nanoparticles in an offset strip-fin microchannel heat sink (MCHS). The base fluid is
solution of 0.5 wt% Carboxymethyl Cellulose (CMC) in water. This study investigates the effects of nanoparticles
concentration, Reynolds number and geometric size of strip-fin on the performance of MCHS from the viewpoint
of both the first and the second thermodynamic law. The results reveal that enhancing the Reynolds number
improves the performance of MCHS by boosting the convective heat transfer coefficient of the working fluid
which favourably reduces the CPU surface temperature and thermal entropy generation rate and importantly
leads to the temperature uniformity of the CPU surface. However, increase in Reynolds number adversely affects
both the pumping power and the frictional entropy generation in the system. Therefore, the optimal strip-fin size
is investigated to find the optimum performance of the offset strip-fins MCHS from the viewpoint of both the first
and the second thermodynamic law. The optimal results show that the highest ratio of heat transfer enhance-
ment to pressure drop increment, using the nanofluid instead of base fluid, is 2.29. In addition in the optimal
case, the minimum total entropy generation rate of the nanofluid is 2.7% less than the base fluid.